Masterand Antibody-Mediated PROTAC Drug Delivery (all genders)
Work Your Magic with us!
Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.
United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.
About the Team
You will become part of a highly motivated team of scientists working at the exciting interface of platform technology development, drug design, and lead candidate nomination. Our team is pioneering a novel, antibody-mediated drug delivery platform specifically tailored for PROTACs (Proteolysis Targeting Chimeras): the PROxAb Shuttle.
Project Description
The central goal of this master thesis is to derive parameters to predict suitability of a PROTAC-antibody pair for treating a given oncology indication. You will systematically screen different PROTAC–antibody combinations on multiple cell lines using cellular assays in a direct-to-biology manner to establish clear selection criteria and structure–activity relationships. Additionally, you will use AI-based tools to handle, analyze, and extract meaningful trends from the large datasets generated.
Your Responsibilities
- Design, implement, and analyze cell viability assay experiments to assess PROTAC–antibody combinations
- Conduct systematic screenings to define payload selection criteria
- Apply AI and data science approaches to process and interpret large experimental datasets to identify trends and derive conclusions
- Present your findings clearly and confidently to a scientific audience
Your Profile
- Currently enrolled in a Master’s program in Biotechnology, Biochemistry, Biomedical Sciences, Molecular Medicine, or Medicinal Chemistry
- Independent and thorough working mode with a strong sense of scientific rigor
- Confidence in structuring and presenting scientific concepts
- Excellent English and fluency in German is mandatory
Join us and contribute to shaping next-generation targeted therapies.
What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!
Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!